Novel and selective small molecule inhibitors and activators for the prolyl hydroxylase domain enzyme
<p>Hypoxia Inducible Factors (HIF) functions are master regulators of oxygen homeostasis and have a key role in the physiological responses to hypoxia including angiogenesis and erythropoiesis. Under hypoxia, levels of HIF-α subunits increase, they hetereodimerise with HIF-1β sub unit and pr...
主要作者: | Holt-Martyn, J |
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其他作者: | Schofield, C |
格式: | Thesis |
出版: |
2018
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