The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.
The Moonwalker (Mwk) mouse is a recent model of dominantly inherited cerebellar ataxia. The motor phenotype of the Mwk mouse is due to a gain-of-function mutation in the gene encoding the cation-permeable transient receptor potential channel (TRPC3). This mutation converts a threonine into an alanin...
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| Format: | Journal article |
| Language: | English |
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2014
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