Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort.
Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the associ...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2012
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| _version_ | 1826271086638006272 |
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| author | Aleksandrova, K Boeing, H Jenab, M Bueno-de-Mesquita, H Jansen, E van Duijnhoven, F Rinaldi, S Fedirko, V Romieu, I Riboli, E Gunter, M Westphal, S Overvad, K Tjønneland, A Halkjær, J Racine, A Boutron-Ruault, M Clavel-Chapelon, F Kaaks, R Lukanova, A Trichopoulou, A Lagiou, P Trichopoulos, D Mattiello, A Pala, V |
| author_facet | Aleksandrova, K Boeing, H Jenab, M Bueno-de-Mesquita, H Jansen, E van Duijnhoven, F Rinaldi, S Fedirko, V Romieu, I Riboli, E Gunter, M Westphal, S Overvad, K Tjønneland, A Halkjær, J Racine, A Boutron-Ruault, M Clavel-Chapelon, F Kaaks, R Lukanova, A Trichopoulou, A Lagiou, P Trichopoulos, D Mattiello, A Pala, V |
| author_sort | Aleksandrova, K |
| collection | OXFORD |
| description | Leptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40-0.76; P(trend) = 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28-0.63, P(trend) = 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48-1.44, P(trend) = 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56-1.29, P(trend) = 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. |
| first_indexed | 2024-03-06T21:51:06Z |
| format | Journal article |
| id | oxford-uuid:4b497ef4-fba4-4d1d-939d-f788ff6bb18a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:51:06Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:4b497ef4-fba4-4d1d-939d-f788ff6bb18a2022-03-26T15:42:43ZLeptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4b497ef4-fba4-4d1d-939d-f788ff6bb18aEnglishSymplectic Elements at Oxford2012Aleksandrova, KBoeing, HJenab, MBueno-de-Mesquita, HJansen, Evan Duijnhoven, FRinaldi, SFedirko, VRomieu, IRiboli, EGunter, MWestphal, SOvervad, KTjønneland, AHalkjær, JRacine, ABoutron-Ruault, MClavel-Chapelon, FKaaks, RLukanova, ATrichopoulou, ALagiou, PTrichopoulos, DMattiello, APala, VLeptin, a peptide hormone produced primarily by the adipocytes, is hypothesized to play a role in the pathogenesis of colorectal cancer (CRC). Soluble leptin receptor (sOB-R) may regulate leptin's physiologic functions; however its relation to CRC risk is unknown. This study explored the association of leptin and sOB-R with risk of CRC in a prospective nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129 incident CRC cases (713 colon, 416 rectal) were matched within risk sets to 1,129 controls. Conditional logistic regression was used to calculate relative risks (RR) and 95% confidence intervals (CI). After multivariable adjustment including body mass index (BMI), waist circumference, and baseline leptin concentrations, sOB-R was strongly inversely associated with CRC (RR comparing the highest quintile vs. the lowest, 0.55; 95% CI, 0.40-0.76; P(trend) = 0.0004) and colon cancer (RR, 0.42; 95% CI, 0.28-0.63, P(trend) = 0.0001); whereas no association was seen for rectal cancer (RR adjusted for BMI and waist circumference, 0.83; 95% CI, 0.48-1.44, P(trend) = 0.38). In contrast, leptin was not associated with risk of CRC (RR adjusted for BMI and waist circumference, 0.85; 95% CI, 0.56-1.29, P(trend) = 0.23). Additional adjustments for circulating metabolic biomarkers did not attenuate these results. These novel findings suggest a strong inverse association between circulating sOB-R and CRC risk, independent of obesity measures, leptin concentrations, and other metabolic biomarkers. Further research is needed to confirm the potentially important role of sOB-R in CRC pathogenesis. |
| spellingShingle | Aleksandrova, K Boeing, H Jenab, M Bueno-de-Mesquita, H Jansen, E van Duijnhoven, F Rinaldi, S Fedirko, V Romieu, I Riboli, E Gunter, M Westphal, S Overvad, K Tjønneland, A Halkjær, J Racine, A Boutron-Ruault, M Clavel-Chapelon, F Kaaks, R Lukanova, A Trichopoulou, A Lagiou, P Trichopoulos, D Mattiello, A Pala, V Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. |
| title | Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. |
| title_full | Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. |
| title_fullStr | Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. |
| title_full_unstemmed | Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. |
| title_short | Leptin and soluble leptin receptor in risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition cohort. |
| title_sort | leptin and soluble leptin receptor in risk of colorectal cancer in the european prospective investigation into cancer and nutrition cohort |
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