Synthesis of enantiopure dihydropyranones: aldol-based ring expansion of dihydrofurans.
[reaction: see text] The stereoselective Birch reduction of 3-methyl-2-furoic acids using a readily available chiral auxilairy is described; by coupling this process to an oxidative cleavage/aldol ring closure sequence we were able to produce highly functionalized and enantiopure dihydropyranones in...
| Glavni autori: | , , , , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2002
|