Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.

We have monitored whole-cell and single channel ATP-sensitive K+ (KATP) currents in isolated rat glucagon-secreting pancreatic A-cells. Tolbutamide produced a concentration-dependent decrease in the whole-cell KATP conductance (Ki = 6 microM) and initiated action potential firing. The K+ channel ope...

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Những tác giả chính: Bokvist, K, Olsen, H, Høy, M, Gotfredsen, C, Holmes, W, Buschard, K, Rorsman, P, Gromada, J
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1999