Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.
We have monitored whole-cell and single channel ATP-sensitive K+ (KATP) currents in isolated rat glucagon-secreting pancreatic A-cells. Tolbutamide produced a concentration-dependent decrease in the whole-cell KATP conductance (Ki = 6 microM) and initiated action potential firing. The K+ channel ope...
主要な著者: | , , , , , , , |
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フォーマット: | Journal article |
言語: | English |
出版事項: |
1999
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