Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.

Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.

Precise control of the innate immune response is essential to ensure host defense against infection while avoiding inflammatory disease. Systems-level analyses of Toll-like receptor (TLR)-stimulated macrophages suggested that SHANK-associated RH domain-interacting protein (SHARPIN) might play a role...

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Bibliographic Details
Main Authors: Zak, D, Schmitz, F, Gold, E, Diercks, A, Peschon, J, Valvo, J, Niemistö, A, Podolsky, I, Fallen, S, Suen, R, Stolyar, T, Johnson, C, Kennedy, K, Hamilton, M, Siggs, O, Beutler, B, Aderem, A
Format: Journal article
Language:English
Published: 2011

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