Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers

Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers

β-Lactams are the most successful antibacterials, but their effectiveness is threatened by resistance, most importantly by production of serine- and metallo-β-lactamases (MBLs). MBLs are of increasing concern because they catalyse the hydrolysis of almost all β-lactam antibiotics, including recent g...

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Detalhes bibliográficos
Main Authors:	Brem, J, van Berkel, S, Zollman, D, Lee, S, Gileadi, O, McHugh, P, Walsh, T, McDonough, M, Schofield, C
Formato:	Journal article
Publicado em:	American Society for Microbiology 2015

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