Structural basis of metallo-β-lactamase inhibition by captopril stereoisomers

β-Lactams are the most successful antibacterials, but their effectiveness is threatened by resistance, most importantly by production of serine- and metallo-β-lactamases (MBLs). MBLs are of increasing concern because they catalyse the hydrolysis of almost all β-lactam antibiotics, including recent g...

詳細記述

書誌詳細
主要な著者: Brem, J, van Berkel, S, Zollman, D, Lee, S, Gileadi, O, McHugh, P, Walsh, T, McDonough, M, Schofield, C
フォーマット: Journal article
出版事項: American Society for Microbiology 2015