Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

Antimalarial compounds with dual therapeutic and transmission-blocking activity are desired as high-value partners for combination therapies. Here, we report the identification and characterization of hexahydroquinolines (HHQs) that show low nanomolar potency against both pathogenic and transmissibl...

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Bibliographic Details
Main Authors:	Vanaerschot, M, Lucantoni, L, Li, T, Combrinck, JM, Ruecker, A, Kumar, TRS, Rubiano, K, Ferreira, PE, Siciliano, G, Gulati, S, Henrich, PP, Ng, CL, Murithi, JM, Corey, VC, Duffy, S, Lieberman, OJ, Veiga, MI, Sinden, RE, Alano, P, Delves, MJ, Sim, K, Winzeler, EA, Egan, TJ, Hoffman, SL, Avery, VM, Fidock, DA
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2017

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

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