Nigral transplants reinnervating the dopamine-depleted neostriatum can sustain intracranial self-stimulation.

Transplants of embryonic substantia nigra reinnervated the striatum and were able to sustain intracranial self-stimulation in rats with brain lesions induced by 6-hydroxydopamine. Dopaminergic drugs and alterations in current intensity produced typical changes in response rates. Animals with electro...

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Bibliographic Details
Main Authors: Fray, P, Dunnett, S, Iversen, S, Björklund, A, Stenevi, U
Format: Journal article
Language:English
Published: 1983