Humanization of antibodies using a machine learning approach on large-scale repertoire data

<p><strong>Motivation:</strong> Monoclonal antibody therapeutics are often produced from non-human sources (typically murine), and can therefore generate immunogenic responses in humans. Humanization procedures aim to produce antibody therapeutics that do not elicit an immune respo...

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Bibliographic Details
Main Authors: Marks, C, Hummer, AM, Chin, M, Deane, C
Format: Journal article
Language:English
Published: Oxford University Press 2021