Optimizing aerosol gene delivery and expression in the ovine lung.

We have developed the sheep as a large animal model for optimizing cystic fibrosis gene therapy protocols. We administered aerosolized gene transfer agents (GTAs) to the ovine lung in order to test the delivery, efficacy, and safety of GTAs using a clinically relevant nebulizer. A preliminary study...

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Bibliographic Details
Main Authors:	McLachlan, G, Baker, A, Tennant, P, Gordon, C, Vrettou, C, Renwick, L, Blundell, R, Cheng, S, Scheule, R, Davies, L, Painter, H, Coles, R, Lawton, A, Marriott, C, Gill, DR, Hyde, S, Griesenbach, U, Alton, E, Boyd, A, Porteous, D, Collie, D
Format:	Journal article
Language:	English
Published:	2007

Optimizing aerosol gene delivery and expression in the ovine lung.

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