Leveraging an open science drug discovery model to develop CNS penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma

There are currently no effective chemotherapeutic drugs approved for the treatment of diffuse intrinsic pontine glioma (DIPG), an aggressive pediatric cancer resident in the pons region of the brainstem. Radiation therapy is beneficial but not curative, with the condition being uniformly fatal. Anal...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Smil, D, Wong, JF, Williams, E, Adamson, R, Howarth, A, McLeod, D, Mamai, A, Kim, S, Wilson, B, Kiyota, T, Aman, A, Owen, J, Poda, G, Horiuchi, K, Kuznetsova, E, Ma, H, Hamblin, JN, Cramp, S, Roberts, O, Edwards, AM, Uehling, D, Al-awar, R, Bullock, AN, O'Meara, J, Isaac, M
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	American Chemical Society 2020

Leveraging an open science drug discovery model to develop CNS penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma

Antzeko izenburuak