Leveraging an open science drug discovery model to develop CNS penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma

There are currently no effective chemotherapeutic drugs approved for the treatment of diffuse intrinsic pontine glioma (DIPG), an aggressive pediatric cancer resident in the pons region of the brainstem. Radiation therapy is beneficial but not curative, with the condition being uniformly fatal. Anal...

Täydet tiedot

Bibliografiset tiedot
Päätekijät:	Smil, D, Wong, JF, Williams, E, Adamson, R, Howarth, A, McLeod, D, Mamai, A, Kim, S, Wilson, B, Kiyota, T, Aman, A, Owen, J, Poda, G, Horiuchi, K, Kuznetsova, E, Ma, H, Hamblin, JN, Cramp, S, Roberts, O, Edwards, AM, Uehling, D, Al-awar, R, Bullock, AN, O'Meara, J, Isaac, M
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	American Chemical Society 2020

Leveraging an open science drug discovery model to develop CNS penetrant ALK2 inhibitors for the treatment of diffuse intrinsic pontine glioma

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