Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates

Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has proven its efficacy both in pre-clinical and early clinical studi...

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Bibliografiska uppgifter
Huvudupphovsmän: Thiam, LG, McHugh, K, Ba, A, Li, R, Guo, Y, Pouye, MN, Cisse, A, Pipini, D, Diallo, F, Sene, SD, Patel, SD, Thiam, A, Sadio, BD, Mbengue, A, Vigan-Womas, I, Sheng, Z, Shapiro, L, Draper, SJ, Bei, AK
Materialtyp: Journal article
Språk:English
Publicerad: Nature Research 2024