Pattern recognition receptor polymorphisms as predictors of oxaliplatin benefit in colorectal cancer

Pattern recognition receptor polymorphisms as predictors of oxaliplatin benefit in colorectal cancer

<strong>Background</strong> Constitutional loss of function (LOF) single nucleotide polymorphisms (SNPs) in pattern recognition receptors FPR1, TLR3 and TLR4 have previously been reported to predict oxaliplatin benefit in colorectal cancer. Confirmation of this association could substant...

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Bibliographic Details
Main Authors: Gray, V, Briggs, S, Palles, C, Jaeger, E, Iveson, T, Kerr, R, Saunders, M, Paul, J, Harkin, A, McQueen, J, Summers, M, Johnstone, E, Wang, H, Gatcombe, L, Maughan, T, Kaplan, R, Escott-Price, V, Al-Tassan, N, Meyer, B, Wakil, S, Houlston, R, Cheadle, J, Tomlinson, I, Church, D
Format: Journal article
Published: Oxford University Press 2019
Subjects:
stratification
genotype determination
toll-like receptor 4
polymorphism
models
biological markers
genetic
medical oncology
cox proportional hazards models
genotype
colorectal cancer
single nucleotide polymorphism
oxaliplatin
pattern recognition receptors
formyl peptide receptors
imputation
functional status

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