The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.

1. The novel tri-aryl ethane CDP840, is a potent and selective inhibitor of cyclic AMP phosphodiesterase type 4 (PDE 4) extracted from tissues or recombinant PDE 4 isoforms expressed in yeast (IC50S: 4-45 nM). CDP840 is stereo-selective since its S enantiomer (CT 1731) is 10-50 times less active aga...

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Bibliographic Details
Main Authors:	Hughes, B, Howat, D, Lisle, H, Holbrook, M, James, T, Gozzard, N, Blease, K, Hughes, P, Kingaby, R, Warrellow, G, Alexander, R, Head, J, Boyd, E, Eaton, M, Perry, M, Wales, M, Smith, B, Owens, R, Catterall, C, Lumb, S, Russell, A, Allen, R, Merriman, M, Bloxham, D, Higgs, G
Format:	Journal article
Language:	English
Published:	1996

The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.

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