N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection.

The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known. NTCP contains two N-linked glycosylation sites and asparagine amino acid residues N5...

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Bibliographic Details
Main Authors: Appelman, M, Chakraborty, A, Protzer, U, McKeating, J, van de Graaf, S
Format: Journal article
Language:English
Published: Public Library of Science 2017