Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
The extreme polymorphism in the human leukocyte antigen (HLA) class I region of the human genome is suggested to provide an advantage in pathogen defence mediated by CD8+ T cells. HLA class I molecules present pathogen-derived peptides on the surface of infected cells for recognition by CD8+ T cells...
मुख्य लेखकों: | , , , , , , , , , , , , , , , , , , , , , , , , |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
2004
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