Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

The extreme polymorphism in the human leukocyte antigen (HLA) class I region of the human genome is suggested to provide an advantage in pathogen defence mediated by CD8+ T cells. HLA class I molecules present pathogen-derived peptides on the surface of infected cells for recognition by CD8+ T cells...

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Detalles Bibliográficos
Autores principales:	Kiepiela, P, Leslie, A, Honeyborne, I, Ramduth, D, Thobakgale, C, Chetty, S, Rathnavalu, P, Moore, C, Pfafferott, K, Hilton, L, Zimbwa, P, Moore, S, Allen, T, Brander, C, Addo, M, Altfeld, M, James, I, Mallal, S, Bunce, M, Barber, L, Szinger, J, Day, C, Klenerman, P, Mullins, J, Korber, B
Formato:	Journal article
Lenguaje:	English
Publicado:	2004

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.

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