G protein-dependent inhibition of L-type Ca2+ currents by acetylcholine in mouse pancreatic B-cells.

1. The effect of acetylcholine (ACh) on voltage-dependent Ca2+ currents in mouse pancreatic B-cells was studied using the whole-cell configuration of the patch-clamp technique. 2. ACh (0.25-250 microM) reversibly and dose-dependently inhibited the Ca2+ current elicited by depolarizations from -80 mV...

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Bibliographic Details
Main Authors: Gilon, P, Yakel, J, Gromada, J, Zhu, Y, Henquin, J, Rorsman, P
Format: Journal article
Language:English
Published: 1997