Biocatalytic production of bicyclic β-lactams with three contiguous chiral centres using engineered crotonases
There is a need to develop asymmetric routes to functionalised β-lactams, which remain the most important group of antibacterials. Here we describe biocatalytic and protein engineering studies concerning carbapenem biosynthesis enzymes, aiming to enable stereoselective production of functionalised c...
| Hlavní autoři: | , , , , , |
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| Médium: | Journal article |
| Vydáno: |
Springer Nature
2019
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