Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks.

Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect against risk of coronary heart disease (CHD), and have prompted the development of a new class of therapeutics. It is uncerta...

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Detalles Bibliográficos
Main Authors: Peloso, G, Auer, P, Bis, J, Voorman, A, Morrison, A, Stitziel, N, Brody, J, Khetarpal, SA, Crosby, JR, Fornage, M, Isaacs, A, Jakobsdottir, J, Feitosa, M, Davies, G, Huffman, J, Manichaikul, A, Davis, B, Lohman, K, Joon, A, Smith, A, Grove, M, Zanoni, P, Redon, V, Demissie, S, Lawson, K
Formato: Journal article
Idioma:English
Publicado: 2014

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