Structural basis for substrate specificity in human monomeric carbonyl reductases.

Structural basis for substrate specificity in human monomeric carbonyl reductases.

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Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to reduce xenobiotics, several of the enzymes act on en...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Pilka, E, Niesen, F, Lee, W, El-Hawari, Y, Dunford, J, Kochan, G, Wsol, V, Martin, H, Maser, E, Oppermann, U
التنسيق: Journal article
اللغة:English
منشور في: 2009
الموضوعات:
methods
chemistry
Isoquinolines
Humans
Crystallography, X-Ray
Cloning, Molecular
Xenobiotics
Substrate Specificity
Kinetics
Mutagenesis, Site-Directed
Structure-Activity Relationship
Alcohol Oxidoreductases
Mutagenesis
Ethanolamines
pharmacology
Temperature
Antineoplastic Agents
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