Structural basis for substrate specificity in human monomeric carbonyl reductases.

Carbonyl reduction constitutes a phase I reaction for many xenobiotics and is carried out in mammals mainly by members of two protein families, namely aldo-keto reductases and short-chain dehydrogenases/reductases. In addition to their capacity to reduce xenobiotics, several of the enzymes act on en...

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Main Authors: Pilka, E, Niesen, F, Lee, W, El-Hawari, Y, Dunford, J, Kochan, G, Wsol, V, Martin, H, Maser, E, Oppermann, U
格式: Journal article
语言:English
出版: 2009
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