Structural basis for antagonism of the ubiquitin ligase BIRC6 by SMAC

Apoptosis, a form of genetically programmed cell death, can be triggered by either internal or external signals ultimately activating caspases, a family of proteases1. Certain members of the inhibitors of apoptosis (IAP) family are sentinel proteins preventing untimely cell death by inhibiting caspa...

Full description

Bibliographic Details
Main Authors: Dietz, L, Ellison, CJ, Riechmann, C, Cassidy, CK, Felfoldi, FD, Pinto-Fernández, A, Kessler, BM, Elliott, PR
Format: Internet publication
Language:English
Published: 2022