Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials

Objectives: Year-to-year variation in respiratory viruses may result in lower attack rates than expected. We aimed to illustrate the impact of year-to-year variation in attack rates on the likelihood of demonstrating vaccine efficacy (VE). Study Design and Setting: We considered an individually rand...

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Bibliographic Details
Main Authors:	Billard, MN, Wildenbeest, J, Bont, LJ, Nair, H, McCracken, JP, Oude Rengerink, K, Marie-Noelle Billard, Bont, L, Campbell, H, Beutels, P, Openshaw, P, Pollard, A, Martinon-Torres, F, Heikkinen, T, Meijer, A, Fischer, TK, van den Berge, M, Giaquinto, C, Aerssens, J, Abram, M, Swanson, K, Demont, C, Gallichan, S, Kumar, V, Stoszek, S, Molero, E
Format:	Journal article
Language:	English
Published:	Elsevier 2022

Year-to-year variation in attack rates could result in underpowered respiratory syncytial virus vaccine efficacy trials

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