Amine landscaping to maximize protein-dye fluorescence and ultrastable protein-ligand interaction

Chemical modification of proteins provides great opportunities to control and visualize living systems. The most common way to modify proteins is reaction of their abundant amines with N-hydroxysuccinimide (NHS) esters. Here we explore the impact of amine number and positioning on protein-conjugate...

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Bibliographic Details
Main Authors: Jacobsen, M, Fairhead, M, Fogelstrand, P, Howarth, M
Format: Journal article
Published: Cell Press 2017