Synthesis and biological evaluation of tripartin, a putative KDM4 natural product inhibitor, and 1‐Dichloromethylinden‐1‐ol analogues
The natural product tripartin has been reported to inhibit the N‐methyl‐lysine histone demethylase KDM4A. A synthesis of tripartin starting from 3,5‐dimethoxyphenylacrylic acid was developed, and the enantiomers were separated by chiral HPLC. We observed that both tripartin enantiomers manifested an...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
John Wiley and Sons, Ltd.
2018
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