A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer

<strong>Background</strong> miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-346 on DNA damage, and its potential as a therapeuti...

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Main Authors: Fletcher, CE, Deng, L, Orafidiya, F, Yuan, W, Lorentzen, MPGS, Cyran, OW, Varela-Carver, A, Constantin, TA, Leach, DA, Dobbs, FM, Figueiredo, I, Gurel, B, Parkes, E, Bogdan, D, Pereira, RR, Zhao, SG, Neeb, A, Issa, F, Hester, J, Kudo, H, Liu, Y, Philippou, Y, Bristow, R, Knudsen, K, Bryant, RJ, Feng, FY, Reed, SH, Mills, IG, de Bono, J, Bevan, CL
Format: Journal article
Language:English
Published: BioMed Central 2022