Carvedilol inhibits cADPR- and IP3-induced Ca2+ release
Spontaneous Ca2+ waves, also termed store-overload-induced Ca2+ release (SOICR), in cardiac cells can trigger ventricular arrhythmias especially in failing hearts. SOICR occurs when Ryanodine receptors (RyRs) are activated by an increase in sarcoplasmic reticulum (SR) luminal Ca2+. Carvedilol is one...
| Principais autores: | , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
American Scientific Publishers
2017
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