Carvedilol inhibits cADPR- and IP3-induced Ca2+ release
Spontaneous Ca2+ waves, also termed store-overload-induced Ca2+ release (SOICR), in cardiac cells can trigger ventricular arrhythmias especially in failing hearts. SOICR occurs when Ryanodine receptors (RyRs) are activated by an increase in sarcoplasmic reticulum (SR) luminal Ca2+. Carvedilol is one...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Scientific Publishers
2017
|