ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.

ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.

(3R,5R)-Clavulanic acid, a clinically used inhibitor of serine beta-lactamases, is produced by fermentation of Streptomyces clavuligerus. The early steps in clavulanic acid biosynthesis leading to the bicyclic beta-lactam intermediate (3S,5S)-clavaminic acid have been defined. However, the mechanism...

Полное описание

Библиографические подробности
Главные авторы:	Arulanantham, H, Kershaw, N, Hewitson, K, Hughes, C, Thirkettle, J, Schofield, C
Формат:	Journal article
Язык:	English
Опубликовано:	2006

Схожие документы

EXPRESSION IN ESCHERICHIA-COLI OF A CLAVAMINIC ACID SYNTHASE ISOZYME - A TRIFUNCTIONAL OXYGENASE INVOLVED IN CLAVULANIC ACID BIOSYNTHESIS
по: Lawlor, E, и др.
Опубликовано: (1994)

STUDIES ON THE STEREOSPECIFICITY OF THE CLAVAMINIC ACID SYNTHASE CATALYZED HYDROXYLATION REACTION
по: Baldwin, J, и др.
Опубликовано: (1993)

ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.
по: Kershaw, N, и др.
Опубликовано: (2002)

Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway.
по: Valegård, K, и др.
Опубликовано: (2013)

Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid.
по: MacKenzie, A, и др.
Опубликовано: (2007)

The origin of the beta-lactam carbons of clavulanic acid
по: Thirkettle, J, и др.
Опубликовано: (1997)

SUBSTRATE-ANALOG STUDIES ON CLAVAMINIC ACID SYNTHASE
по: Baldwin, J, и др.
Опубликовано: (1993)

Chemistry and biosynthesis of clavulanic acid and other clavams.
по: Baggaley, K, и др.
Опубликовано: (1997)

X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.
по: Elkins, J, и др.
Опубликовано: (2005)

Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
по: Iqbal, A, и др.
Опубликовано: (2010)

Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.
по: Elkins, J, и др.
Опубликовано: (2002)

ISOLATION OF AN INTERMEDIATE IN CLAVULANIC ACID BIOSYNTHESIS
по: Baldwin, J, и др.
Опубликовано: (1990)

ISOLATION OF DIHYDROCLAVAMINIC ACID, AN INTERMEDIATE IN THE BIOSYNTHESIS OF CLAVULANIC ACID
по: Baldwin, J, и др.
Опубликовано: (1991)

Mutagenesis studies on the iron binding ligands of clavaminic acid synthase.
по: Doan, L, и др.
Опубликовано: (2000)

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
по: Zhang, Z, и др.
Опубликовано: (2000)

Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway.
по: Caines, M, и др.
Опубликовано: (2004)

ENZYMATIC-SYNTHESIS OF BICYCLIC GAMMA-LACTAMS USING CLAVAMINIC ACID SYNTHASE
по: Baldwin, J, и др.
Опубликовано: (1992)

Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies.
по: Borowski, T, и др.
Опубликовано: (2007)

Chemo-enzymatic synthesis of bicyclic gamma-lactams using clavaminic acid synthase
по: Baldwin, J, и др.
Опубликовано: (1997)

A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID
по: Baldwin, J, и др.
Опубликовано: (1993)

X-ray absorption spectroscopic studies of the iron(II) active site of clavaminic acid synthase.
по: Baldwin, J, и др.
Опубликовано: (1997)

Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
по: Iqbal, A
Опубликовано: (2008)

Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.
по: Mackenzie, A, и др.
Опубликовано: (2010)

Product-substrate engineering by bacteria: Studies on clavaminate synthase, a trifunctional dioxygenase
по: Lloyd, MD, и др.
Опубликовано: (1999)

Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives.
по: Brown, R, и др.
Опубликовано: (1997)

Serotonin syndrome induced by amoxicillin–clavulanic acid
по: L. Naya Ríos, и др.
Опубликовано: (2024-04-01)

Amoxycillin-clavulanic acid treatment of melioidosis.
по: Suputtamongkol, Y, и др.
Опубликовано: (1991)

Clavulanic Acid Adsorption Studies in Zeolites
по: Marcus Bruno Soares Forte, и др.
Опубликовано: (2011-05-01)

Overproduction of clavulanic acid by extractive fermentation
по: Cecília Ladeira Lopes Costa, и др.
Опубликовано: (2015-05-01)

Kinetic and Mechanistic Studies on the Interaction of Glycyl-L-alanine, Glycyl-L-asparagine, and Glycyl-L-tyrosine with Hydroxopentaaquarhodium(III) Ion
по: Biplab K. Bera, и др.
Опубликовано: (2013-01-01)

Bibliometric Analysis of Global Research on Clavulanic Acid
по: Howard Ramirez-Malule
Опубликовано: (2018-11-01)

Electrochemical Study of Complex Formation of Cerium (IV) Ion with Glycyl-Glycine and Glycyl-Valine
по: Farhoush Kiani, и др.
Опубликовано: (2011-01-01)

Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements.
по: Zhang, Z, и др.
Опубликовано: (2002)

The activity of amoxycillin/clavulanic acid against Pseudomonas pseudomallei.
по: Dance, D, и др.
Опубликовано: (1989)

Amoxicillin/clavulanic acid-induced pancreatitis: case report
по: Sana Chams, и др.
Опубликовано: (2018-08-01)

Clavulanic acid improves ethanol withdrawal symptoms in rats
по: Ehsan Mohebi, и др.
Опубликовано: (2020-06-01)

Streptomyces clavuligerus strain selection for clavulanic acid biosynthesis: a study based on culture composition effects and statistical analysis
по: Laura Pinilla, и др.
Опубликовано: (2018-04-01)

Environmental Factors Modulate the Role of <i>orf21</i> Sigma Factor in Clavulanic Acid Production in <i>Streptomyces Clavuligerus</i> ATCC27064
по: Luisa F. Patiño, и др.
Опубликовано: (2022-02-01)

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.
по: Brown, R, и др.
Опубликовано: (1996)

Glycyl-glutamine supplementation and high dose therapy
по: Maughan, T, и др.
Опубликовано: (1995)