Scc2 is a potent activator of Cohesin’s ATPase that promotes loading by binding Scc1 without Pds5

Scc2 is a potent activator of Cohesin’s ATPase that promotes loading by binding Scc1 without Pds5

Cohesin organizes DNA into chromatids, regulates enhancer-promoter interactions, and confers sister chromatid cohesion. Its association with chromosomes is regulated by hook-shaped HEAT repeat proteins that bind Scc1, namely Scc3, Pds5, and Scc2. Unlike Pds5, Scc2 is not a stable cohesin constituent...

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Hlavní autoři: Petela, N, Gligoris, T, Metson, J, Lee, B, Voulgaris, M, Hu, B, Kikuchi, S, Chapard, C, Chen, W, Rajendra, E, Srinivisan, M, Yu, H, Löwe, J, Nasmyth, K
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2018

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