Hsp90 inhibitors reduce influenza virus replication in cell culture.

The viral RNA polymerase complex of influenza A virus consists of three subunits PB1, PB2 and PA. Recently, the cellular chaperone Hsp90 was shown to play a role in nuclear import and assembly of the trimeric polymerase complex by binding to PB1 and PB2. Here we show that Hsp90 inhibitors, geldanamy...

詳細記述

書誌詳細
主要な著者: Chase, G, Deng, T, Fodor, E, Leung, B, Mayer, D, Schwemmle, M, Brownlee, G
フォーマット: Journal article
言語:English
出版事項: 2008