A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relationship to chronic lymphocytic leukemia

Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein (oxLDL), apoptotic cells and several pathogens like Streptococcus pneumoniae. Immunoglobulin M against PC (IgM anti-PC) has the ability to inhibit uptake of oxLDL by macrophages and increase clearance of apoptotic cells. From o...

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Prif Awduron:	Chen, X, Gustafsson, S, Whitington, T, Borné, Y, Lorentzen, E, Sun, J, Almgren, P, Su, J, Karlsson, R, Song, J, Lu, Y, Zhan, Y, Hägg, S, Svensson, P, Smedby, K, Slager, S, Ingelsson, E, Lindgren, C, Morris, A, Melander, O, Karlsson, T, de Faire, U, Caidahl, K, Engström, G, Lind, L, Karlsson, M, Pedersen, N, Frostegård, J, Magnusson, P
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Oxford University Press 2018

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