The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus

The role of the light chain in the structure and binding activity of two cattle antibodies that neutralize bovine respiratory syncytial virus

Cattle antibodies have unusually long CDR3 loops in their heavy chains (HCs), and limited light chain (LC) diversity, raising the question of whether these mask the effect of LC variation on antigen recognition. We have investigated the role of the LC in the structure and activity of two neutralizin...

Полное описание

Библиографические подробности
Главные авторы:	Ren, J, Nettleship, J, Harris, G, Mwangi, W, Rhaman, N, Grant, C, Kotecha, A, Fry, E, Charleston, B, Stuart, D, Hammond, J, Owens, R
Формат:	Journal article
Язык:	English
Опубликовано:	Elsevier 2019

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