A mathematical framework for developing freezing protocols in the cryopreservation of cells

When cooling cells to preserve them during cryopreservation, cooling too quickly results in the formation of lethal intracellular ice, while cooling too slowly amplifies the toxic effects of the cryoprotective agents (CPAs) added to slow down ice formation. We derive a mathematical model for cell cr...

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Bibliographic Details
Main Authors: Dalwadi, M, Waters, S, Byrne, H, Hewitt, I
Format: Journal article
Language:English
Published: Society for Industrial and Applied Mathematics 2020