Characterisation of Topoisomerase 1-cleavage complex repair
<p>Topoisomerase 1 (TOP1) resolves DNA topological stress ahead of DNA replication and transcription. As part of its enzymatic activity, TOP1 covalently binds to DNA, creating an intermediate known as TOP1 cleavage complex (TOP1cc) and a single strand DNA break which allows DNA to unwind. If n...
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| Format: | Thesis |
| Language: | English |
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2024
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