Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.

A B lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component. lyn-/- B cells have a delayed but increased calcium fl...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Cornall, R, Cyster, J, Hibbs, M, Dunn, A, Otipoby, K, Clark, E, Goodnow, C
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 1998