Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.
A B lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component. lyn-/- B cells have a delayed but increased calcium fl...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1998
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| _version_ | 1826271816817049600 |
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| author | Cornall, R Cyster, J Hibbs, M Dunn, A Otipoby, K Clark, E Goodnow, C |
| author_facet | Cornall, R Cyster, J Hibbs, M Dunn, A Otipoby, K Clark, E Goodnow, C |
| author_sort | Cornall, R |
| collection | OXFORD |
| description | A B lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component. lyn-/- B cells have a delayed but increased calcium flux and exaggerated negative selection responses in the presence of antigen and spontaneous hyperactivity in the absence of antigen. As in invertebrates, genetic effects of loci with only one functional allele can be used to analyze signaling networks in mice, demonstrating that negative regulation of the BCR is a complex quantitative trait in which Lyn, the coreceptor CD22, and the tyrosine phosphatase SHP-1 are each limiting elements. The biochemical basis of this complex trait involves a pathway requiring Lyn to phosphorylate CD22 and recruit SHP-1 to the CD22/BCR complex. |
| first_indexed | 2024-03-06T22:02:42Z |
| format | Journal article |
| id | oxford-uuid:4f22797e-572b-47c5-8c32-91fed7d87d32 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:02:42Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:4f22797e-572b-47c5-8c32-91fed7d87d322022-03-26T16:05:17ZPolygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4f22797e-572b-47c5-8c32-91fed7d87d32EnglishSymplectic Elements at Oxford1998Cornall, RCyster, JHibbs, MDunn, AOtipoby, KClark, EGoodnow, CA B lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component. lyn-/- B cells have a delayed but increased calcium flux and exaggerated negative selection responses in the presence of antigen and spontaneous hyperactivity in the absence of antigen. As in invertebrates, genetic effects of loci with only one functional allele can be used to analyze signaling networks in mice, demonstrating that negative regulation of the BCR is a complex quantitative trait in which Lyn, the coreceptor CD22, and the tyrosine phosphatase SHP-1 are each limiting elements. The biochemical basis of this complex trait involves a pathway requiring Lyn to phosphorylate CD22 and recruit SHP-1 to the CD22/BCR complex. |
| spellingShingle | Cornall, R Cyster, J Hibbs, M Dunn, A Otipoby, K Clark, E Goodnow, C Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. |
| title | Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. |
| title_full | Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. |
| title_fullStr | Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. |
| title_full_unstemmed | Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. |
| title_short | Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. |
| title_sort | polygenic autoimmune traits lyn cd22 and shp 1 are limiting elements of a biochemical pathway regulating bcr signaling and selection |
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