The first example of a 6-C-aryl-D-glucose: Inhibition of glucokinase

The first example of a 6-C-aryl-D-glucose: Inhibition of glucokinase

The synthesis of the epimeric 6-C-phenylglucoses is reported; these are the first compounds with one of the prochiral methylene hydrogens on C-6 of a hexose being replaced by an aryl group. Both isomers inhibit glucokinase and provide further indications that 6-C-alkyl- and 6-C-aryl-carbohydrates ma...

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Bibliographic Details
Main Authors:	Bleriot, Y, Veighey, C, Smelt, K, Cadefau, J, Stalmans, W, Biggadike, K, Lane, A, Muller, M, Watkin, D, Fleet, G
Format:	Journal article
Language:	English
Published:	1996

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