Generation of chimeric P-glycoprotein for functional and structural investigations
<p>A major challenge in cancer treatment is acquired or intrinsic multidrug resistance (MDR) to chemotherapeutics. A notorious mediator of MDR is P-glycoprotein (P-gp, ABCB1), product of the human <em>MDR1</em> gene, which actively effluxes cytotoxic drugs from cancer cells, result...
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| Format: | Thesis |
| Language: | English |
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2015
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