Rapidly escalating hepcidin and associated serum iron starvation are features of the acute response to typhoid infection in humans

Background: Iron is a key pathogenic determinant of many infectious diseases. Hepcidin, the hormone responsible for governing systemic iron homeostasis, is widely hypothesized to represent a key component of nutritional immunity through regulating the accessibility of iron to invading microorganisms...

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Bibliographic Details
Main Authors: Darton, T, Blohmke, C, Giannoulatou, E, Waddington, C, Jones, C, Sturges, P, Webster, C, Drakesmith, H, Pollard, A, Armitage, A
Format: Journal article
Published: Public Library of Science 2015