Mechanisms of creatine depletion in chronically failing rat heart.

The failing myocardium is characterised by energetic imbalance, reflected by reduced phosphocreatine and creatine content. These changes may contribute to cardiac dysfunction, yet mechanisms of creatine and phosphocreatine depletion are poorly understood. Creatine is taken up by the heart via the cr...

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Bibliographic Details
Main Authors: Ten Hove, M, Chan, S, Lygate, C, Monfared, M, Boehm, E, Hulbert, K, Watkins, H, Clarke, K, Neubauer, S
Format: Conference item
Published: 2005