The effects of hypomorphic STAT3 on lymphocyte function and intestinal immune regulation

<p>Dominant-negative mutations in signal transducer and activator of transcription 3 (STAT3) underlie the human primary immunodeficiency autosomal dominant hyper IgE syndrome (HIES). A number of aspects of this disease, including the eponymous elevated serum IgE, remain poorly understood. Addi...