FTO demethylase activity is essential for normal bone growth and bone mineralization in mice

The Fto gene locus has been linked to increased body weight and obesity in human population studies, but the role of the actual FTO protein in adiposity has remained controversial. Complete loss of FTO protein in mouse and of FTO function in human patients has multiple and variable effects. To deter...

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Bibliographic Details
Main Authors: Sachse, G, Church, C, Stewart, M, Cater, H, Teboul, L, Cox, RD, Ashcroft, FM
Format: Journal article
Language:English
Published: Elsevier 2017