Immune recognition of HLA molecules downmodulates CD8 expression on cytotoxic T lymphocytes.
An HLA-A2+ cytotoxic T lymphocyte (CTL) line restricted by HLA-A2 in recognition of an influenza B virus nucleoprotein (BNP) peptide uses the CD8 coreceptor in the recognition of this viral peptide. Incubation of these CTL with BNP peptide in the absence of antigen-presenting cells downmodulates CD8...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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