Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF

Hypoxia-inducible factor is expressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF

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Hypoxia is an important regulator of bone biology and stimulates osteoclast differentiation from monocytic precursors. Hypoxia-inducible factor (HIF) is a key pro-tumourigenic transcription factor mediating pathways of hypoxia-inducible gene expression. We have described expression of HIF-1α and HIF...

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Bibliografiske detaljer
Main Authors:	Knowles, H, Athanasou, N
Format:	Journal article
Sprog:	English
Udgivet:	John Wiley & Sons, Ltd. 2008
Fag:	Biology (medical sciences) Cell Biology (see also Plant sciences) Oncology Tumours Tumour pathology Pathology

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